The amino acid AICAR has been shown to enhance the use of the body’s food storage to generate more energy. Users may get it in powder form, which is tan in color. Although it is available for purchase, it is exclusively for the specific purpose of scientific research and study on animal test subjects. Acadesine and ZM are sometimes used to identify the peptide.
To do scientific research on animals, you must first understand the peptide’s mechanism of action and how it is delivered into the system.
To summarize, AICAR stimulates glucose absorption in skeletal muscle tissue while boosting the activity of p38 mitogen-activated protein kinases A and B.
Apoptosis, the process of cellular death that occurs in animal test subjects, is also prevented by its ability to reduce reactive oxygen molecules in cells. To put it another way, it increases the sort of fuel needed to maintain and regulate skeletal muscle tissue while also extending the lifespan of cells.
The Salk Institute undertook a series of investigations on laboratory rats in 2008 to determine the precise role of AICAR. According to this study, the mice administered AICAR showed a considerable increase in endurance-type exercise performance. AICAR’s ability to convert fast-twitch muscle fibers to slow-twitch muscle fibers has been believed to be responsible for this specific benefit. The lab rats’ energy efficiency improved significantly due to this switch. It was also shown that animal test participants had a more efficient method of losing weight due to the change in diet.
Treatment of Ischemic Injuries with AICAR
In other scientific studies, including animal test subjects, the peptide inhibits Adenosine kinase and Adenosine Deaminase in cardiac cells. Only under circumstances of cardiac ischemia does this mechanism increase the rate of nucleotide resynthesis and raise adenosine production from adenosine monophosphate.
There are several theories on how the peptide might be used to treat and protect against various cardiac ischemia injuries, which can be either asymptomatic or brought on by angina pectoris, predominantly induced by arteriosclerosis and divided into three major types.
- Stable angina is a kind of chest pain that occurs due to moderate exertion. When an activity is halted, this state usually goes away within a few minutes.
- Angina that fluctuates or worsens over time is known as unstable angina and is a kind of acute coronary syndrome known as crescendo angina.
- There are several theories about the cause of microvascular angina. Still, the most common one is that it is caused by blood veins in the heart and limbs and legs contracting abnormally, causing angina-like chest discomfort.
Using AICAR’s capabilities, it is hypothesized that ischemia damage may be prevented by keeping the heart muscle from being deprived of blood flow. A decreased risk of cardiac failure in animal test participants would thus be possible due to this peptide. As a result of the increased blood flow, it would be possible to aid in the treatment of an animal test subject who had suffered ischemic damage.
Using AICAR for your scientific research on animals is a great idea, but you need to take a few procedures to ensure that your findings are as accurate as possible.
There are a few things to keep in mind while determining the purity of peptides before you begin your research, particularly if your study spans an extended period, such as many years. If you’re using AICAR in animal testing, you should double-check the amount you’ll be getting to make sure it’s enough for your research needs. You can buy AICAR peptide case you are a licensed professional.
Lastly, keep in mind that AICAR is now in the research phase. Any study on its functioning and effects on animal test subjects should be conducted in a carefully controlled setting like a laboratory or a medical research institution.